Hermes-Simplex was a German car brand from the early 1900s.
The car salesman Émile Mathis and the engineer Ettore Bugatti had met at De Dietrich . Mathis led a major trading house for automobiles and engaged Bugatti as a designer for the new brand, which was to offer high-priced automobiles from 1904. The vehicles were manufactured by the Société Alsacienne de Construction Mécanique in Graffenstaden (SACM). In 1906 they ended their cooperation. Mathis produced from 1910 cars under his name Mathis (E.E.C. Mathis) .
Sporty vehicles were produced with large four-cylinder engines . The model 40/50 hp had a displacement of 7430 cc, the 50/60 hp either over 8480 cc or 8986 cc and the 80/90 hp over 12058 cc displacement. The vehicles were also used in car racing.